PRMT5-mediated arginine methylation of FXR1 is essential for RNA binding in cancer cells.

Anitha Vijayakumar, Mrinmoyee Majumder, Shasha Yin, Charles Brobbey, Joseph Karam, B. Howley, Philip H Howe, Stefano Berto, Lalima K. Madan, Wenjian Gan, Viswanathan Palanisamy

Nucleic Acids Research, 2024

Autophagy dictates sensitivity to PRMT5 inhibitor in breast cancer

Charles Brobbey, Shasha Yin, Liu Liu, L. Ball, P. Howe, J. Delaney, W. Gan

Scientific Reports, 2023

CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

Shasha Yin, Liu Liu, L. Ball, Yalong Wang, M. Bedford, S. Duncan, Haizhen Wang, W. Gan

Cell Reports, 2023

Generating a murine PTEN null cell line to discover the key role of p110β-PAK1 in Castration-Resistant Prostate Cancer invasion.

Haizhen Wang, Yu Zhou, C. Chu, Jialing Xiao, Shanshan Zheng, M. Korpal, Joshua M. Korn, Tiffany Penaloza, Richard R Drake, W. Gan, Xueliang Gao

Molecular Cancer Research, 2023

TRAF6 Promotes PRMT5 Activity in a Ubiquitination-Dependent Manner

Liu Liu, Shasha Yin, W. Gan

Cancers, 2023

Arginine methylation of BRD4 by PRMT2/4 governs transcription and DNA repair

Liu Liu, Baicheng Lin, Shasha Yin, L. Ball, J. Delaney, David T. Long, W. Gan

Science Advances, 2022

DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway

Liu Liu, Xiaoming Dai, Shasha Yin, Pengda Liu, Elizabeth G. Hill, Wenyi Wei, W. Gan

Science Signaling, 2022

PRMT1 and PRMT5: on the road of homologous recombination and non-homologous end joining

Shasha Yin, Liu Liu, W. Gan

Genome Instability & Disease, 2022

The Role of Protein Arginine Methyltransferases in DNA Damage Response

Charles Brobbey, Liu Liu, Shasha Yin, W. Gan

International Journal of Molecular Sciences, 2022

Genetic fusions favor tumorigenesis through degron loss in oncogenes

Jing Liu, Collin J Tokheim, Jonathan D. Lee, W. Gan, Brian J. North, Shirley Liu, P. Pandolfi, Wenyi Wei

Nature Communications, 2021

PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis

Shasha Yin, Liu Liu, Charles Brobbey, Viswanathan Palanisamy, L. Ball, S. Olsen, Michael C. Ostrowski, W. Gan

Nature Communications, 2021

The Roles of Post-Translational Modifications on mTOR Signaling

Shasha Yin, Liu Liu, W. Gan

International Journal of Molecular Sciences, 2021

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control

W. Gan, Xiaoming Dai, Xiangpeng Dai, Jun Xie, Shasha Yin, Junjie Zhu, Chen Wang, Yuchen Liu, Jian-ping Guo, Min Wang, Jing Liu, Jia Hu, Ryan J. Quinton, Neil J. Ganem, Pengda Liu, J. Asara, P. Pandolfi, Yingzi Yang, Zhigang He, G. Gao, Wenyi Wei

Nature Cell Biology, 2020

Ubiquitination in cancer stem cell: roles and targeted cancer therapy

Liu Liu, Shasha Yin, Charles Brobbey, W. Gan

2020

Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1

Wantae Kim, Y. Cho, Xiaohui L. Wang, Ogyi Park, Xueyan Ma, Hanjun Kim, W. Gan, E. Jho, B. Cha, Yunsuk Jeung, Lei Zhang, B. Gao, Wenyi Wei, Jin Jiang, K. Chung, Yingzi Yang

Proceedings of the National Academy of Sciences of the United States of America, 2019

PTEN Methylation by NSD2 Controls Cellular Sensitivity to DNA Damage.

Jinfang Zhang, Yu-Ru Lee, Fabin Dang, W. Gan, Archita V. Menon, Jesse Katon, Chih-Hung Hsu, J. Asara, Priyanka Tibarewal, N. Leslie, Yang Shi, P. Pandolfi, Wenyi Wei

Cancer Discovery, 2019

SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression.

Jinfang Zhang, Ming Chen, Yasheng Zhu, Xiangpeng Dai, Fabin Dang, Junming Ren, S. Ren, Yulia V. Shulga, F. Beca, W. Gan, Fei Wu, Yu-Min Lin, Xiaobo Zhou, J. Decaprio, Andy H. Beck, K. Lu, Jiaoti Huang, C. Zhao, Yinghao Sun, Xu Gao, P. Pandolfi, Wenyi Wei

Developmental Cell, 2019

Akt methylation by SETDB1 promotes Akt kinase activity and oncogenic functions

Jian-ping Guo, Xiangpeng Dai, B. Laurent, Nana Zheng, W. Gan, Jian Zhang, A. Guo, Min Yuan, Pengda Liu, J. Asara, A. Toker, Yang Shi, P. Pandolfi, Wenyi Wei

Nature Cell Biology, 2018

K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair

Pengda Liu, W. Gan, Siyuan Su, Arthur V. Hauenstein, T. Fu, B. Brasher, C. Schwerdtfeger, A. Liang, Ming Xu, Wenyi Wei

Science Signaling, 2018

The mTOR–S6K pathway links growth signalling to DNA damage response by targeting RNF168

Xiaoduo Xie, Hongli Hu, Xinyuan Tong, Long Li, Xiangyuan Liu, Min Chen, Huairui Yuan, Xiaopeng Xie, Qingrun Li, Yuxue Zhang, H. Ouyang, Mengqi Wei, J. Huang, Pengda Liu, W. Gan, Yong Liu, Anyong Xie, Xiao-ling Kuai, G. Chirn, Hu Zhou, Rong Zeng, Ronggui Hu, Jun Qin, Fei-Long Meng, Wenyi Wei, H. Ji, Daming Gao

Nature Cell Biology, 2018

The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth

Jianjun Zhang, Jian-ping Guo, X. Qin, Bin Wang, Linli Zhang, Yingnan Wang, W. Gan, P. Pandolfi, Wantao Chen, Wenyi Wei

Science Signaling, 2018

Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation.

Fei Wu, Xiangpeng Dai, W. Gan, L. Wan, Min Li, N. Mitsiades, Wenyi Wei, Q. Ding, Jinfang Zhang

Cancer Letters, 2017

Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

Xiangpeng Dai, W. Gan, Xiaoning Li, Shangqian Wang, Wei Zhang, Ling Huang, Shengwu Liu, Q. Zhong, Jian-ping Guo, Jinfang Zhang, Ting Chen, K. Shimizu, F. Beca, Mirjam Blattner, Divya Vasudevan, Dennis L. Buckley, J. Qi, Lorenz Buser, Pengda Liu, H. Inuzuka, Andrew H. Beck, Liewei Wang, P. Wild, L. Garraway, M. Rubin, C. Barbieri, Kwok-kin Wong, S. Muthuswamy, Jiaoti Huang, Yu Chen, J. Bradner, Wenyi Wei

Nature Network Boston, 2017

The mTOR-S6K Pathway Links Growth Signaling to DNA Damage Response by Targeting RNF168

Xiaoduo Xie, Hongli Hu, Xinyuan Tong, Long Li, Xiangyuan Liu, Min Chen, Huairui Yuan, Xiaopeng Xie, Qingrun Li, Yuxue Zhang, H. Ouyang, Mengqi Wei, Jing Huang, Pengda Liu, W. Gan, Yong Liu, Anyong Xie, Xiao-ling Kuai, G. Chirn, Hu Zhou, Rong Zeng, Ronggui Hu, J. Qin, Fei-Long Meng, Wenyi Wei, H. Ji, Daming Gao

Nature Cell Biology, 2017

TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling

Bin Wang, Bin Wang, Zuliang Jie, Donghyun Joo, A. Ordureau, Pengda Liu, W. Gan, Jian-ping Guo, Jinfang Zhang, Brian J. North, Xiangpeng Dai, Xuhong Cheng, X. Bian, Lingqiang Zhang, J. Harper, Shao Cong Sun, Wenyi Wei

Nature, 2017

Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells.

Linli Zhang, S. Peng, Xiangpeng Dai, W. Gan, Xin Nie, Wenyi Wei, G. Hu, Jian-ping Guo

Cancer Letters, 2017

Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt.

Jinfang Zhang, Kai Xu, Kai Xu, Pengda Liu, Y. Geng, Bin Wang, Bin Wang, W. Gan, Jian-ping Guo, Fei Wu, Fei Wu, Y. R. Chin, C. Berrios, Evan C. Lien, A. Toker, J. Decaprio, P. Sicinski, Wenyi Wei

Molecules and Cells, 2016

pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner

Jian-ping Guo, A. Chakraborty, Pengda Liu, W. Gan, Xingnan Zheng, H. Inuzuka, Bin Wang, Jinfang Zhang, Linli Zhang, Min Yuan, Jesse S. Novak, J. Cheng, A. Toker, S. Signoretti, Qing Zhang, J. Asara, W. Kaelin, Wenyi Wei

Science, 2016

Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair.

Pengda Liu, W. Gan, Chunguang Guo, Anyong Xie, Daming Gao, Jian-ping Guo, Jinfang Zhang, Nicholas A. Willis, A. Su, J. Asara, R. Scully, Wenyi Wei

Molecules and Cells, 2015

Akt promotes tumorigenesis in part through modulating genomic instability via phosphorylating XLF

W. Gan, Pengda Liu, Wenyi Wei

The Nucleus, 2015

Cell cycle status dictates effectiveness of rapamycin

W. Gan, Pengda Liu, Wenyi Wei

Cell Cycle, 2015

-Dependent Activation of the mTORC2 Kinase Complex

Pengda Liu, W. Gan, Y. R. Chin, K. Ogura, Jian-ping Guo, Jinfang Zhang, Bin Wang, J. Blenis, L. Cantley, A. Toker, Bing Su, Wenyi Wei

2015

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

Pengda Liu, W. Gan, Y. R. Chin, K. Ogura, Jian-ping Guo, Jinfang Zhang, Bin Wang, J. Blenis, L. Cantley, A. Toker, B. Su, Bing Su, Wenyi Wei

Cancer Discovery, 2015

SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.

W. Gan, Xiangpeng Dai, A. Lunardi, Zhen Li, H. Inuzuka, Pengda Liu, Shoreh Varmeh, Jinfang Zhang, Liang Cheng, Yin Sun, J. Asara, Andy H. Beck, Jiaoti Huang, P. Pandolfi, Wenyi Wei

Molecules and Cells, 2015

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Pengda Liu, M. Begley, W. Michowski, H. Inuzuka, M. Ginzberg, Daming Gao, P. Tsou, W. Gan, Antonella Papa, B. Kim, L. Wan, Amrik J Singh, B. Zhai, Min Yuan, Zhiwei Wang, S. Gygi, T. Lee, K. Lu, A. Toker, P. Pandolfi, J. Asara, M. Kirschner, P. Sicinski, L. Cantley, Wenyi Wei

Nature, 2014

Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity

Pengda Liu, Jian-ping Guo, W. Gan, Wenyi Wei

Protein & Cell, 2014

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis

Pengda Liu, W. Gan, H. Inuzuka, A. Lazorchak, Daming Gao, O. Arojo, Dou Liu, L. Wan, B. Zhai, Yonghao Yu, Min Yuan, B. Kim, S. Shaik, Suchithra Menon, S. Gygi, T. Lee, J. Asara, B. Manning, J. Blenis, B. Su, Wenyi Wei

Nature Cell Biology, 2013

Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1

Y. Kanehiro, K. Todo, Misaki Negishi, Junji Fukuoka, W. Gan, Takuya Hikasa, Y. Kaga, Masayuki Takemoto, M. Magari, Xialu Li, J. Manley, H. Ohmori, N. Kanayama

Proceedings of the National Academy of Sciences of the United States of America, 2012

R-loop-mediated genomic instability is caused by impairment of replication fork progression.

W. Gan, Zhishuang Guan, Jie Liu, T. Gui, K. Shen, J. Manley, Xialu Li

Genes & Development, 2011

Two BTB proteins function redundantly as negative regulators of defense against pathogens in Arabidopsis

Na Qu, W. Gan, Dongling Bi, Shitou Xia, Xin Li, Yuelin Zhang

2010